[1]杨冬,贾彤彤,雷蕾,等.静电纺丝技术制备医用敷料的研究进展[J].高分子通报,2022,(09):1-7.[doi:10.14028/j.cnki.1003-3726.2022.09.001]
 YANG Dong,JIA Tong-tong,LEI Lei,et al.The Development of Electrospinning Technology in Medical Dressings[J].POLYMER BULLETIN,2022,(09):1-7.[doi:10.14028/j.cnki.1003-3726.2022.09.001]
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静电纺丝技术制备医用敷料的研究进展()
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《高分子通报》[ISSN:1003-3726/CN:11-2051/O6]

卷:
期数:
2022年09期
页码:
1-7
栏目:
出版日期:
2022-09-20

文章信息/Info

Title:
The Development of Electrospinning Technology in Medical Dressings
作者:
杨冬124 贾彤彤124 雷蕾124 杨凯棣124 高可奕124 王丽霞124 薛朝华3
1. 陕西科技大学化学与化工学院, 西安 710021;
2. 中国轻工业轻化工助剂重点实验室, 西安 710021;
3. 陕西科技大学轻工科学与工程学院, 西安 710021;
4. 西安市先端性能材料与高分子重点实验室, 西安 710021
Author(s):
YANG Dong124 JIA Tong-tong124 LEI Lei124 YANG Kai-di124 GAO Ke-yi124 WANG Li-xia124 XUE Chao-hua3
1. College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China;
2. Key Laboratory of Chemical Additives for China National Light Industry, Xi’an 710021, China;
3. College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China;
4. Xi’an Key Laboratory of Advanced Performance Materials and Polymers, Shaanxi University of Science and Technology, Xi’an 710021, China
关键词:
静电纺丝生物活性材料敷料抗菌伤口愈合
Keywords:
ElectrospinningBioactive materialDressingAntibacterialWound healing
DOI:
10.14028/j.cnki.1003-3726.2022.09.001
文献标志码:
A
摘要:
作为一种先进的创面敷料,静电纺纳米医用敷料与传统敷料相比,有着与人体天然细胞外基质(ECM)高度类似的疏松多孔的结构,可以有效调节细胞增殖过程、加速创面闭合,在促进皮肤愈合方面表现出极大的优势。不仅如此,研究表明将药物和生物活性物质负载在电纺纳米纤维中可以实现缓释的作用,为创面的愈合提供了有利条件,显著提高愈合速度,可作为一种性能优越的医用敷料推广到临床应用中。基于目前的研究,本文对静电纺丝技术的基本原理及静电纺医用敷料的特点进行了简单的介绍,随后根据电纺基材的种类进行了分类,分别为天然、合成和复合电纺敷料,并对其应用进行了讨论。最后,本文提出了现阶段静电纺医用敷料的电纺工艺和抗菌实验存在的一些问题,对电纺敷料用于仿生皮肤研究的前景进行了展望。
Abstract:
Electrospun nano-medical dressing is an advanced wound dressing. Compared with traditional dressings, it has a loose and porous structure that is highly similar to the human body’s natural extracellular matrix (ECM), which can effectively regulate cell proliferation and accelerate wound closure. It shows great advantages in promoting skin growth and healing. Not only that, studies have shown that loading drugs and biologically active substances in electrospun nanofibers can achieve sustained release. This feature can provide convenient conditions for the growth of damaged tissues within an effective time. The electrospun fiber membrane can significantly improve the healing speed, and can be promoted to clinical applications as a medical dressing with superior performance. Based on the current research, this article briefly introduces the basic principles of electrospinning technology and the characteristics of electrospinning medical dressings. Subsequently, according to the types of electrospun substrates, they were classified into natural electrospun dressings, synthetic electrospun dressings and composite electrospun dressings. The characteristics and antibacterial capabilities of various dressings were discussed in detail. Finally, some problems in the electrospinning process and antibacterial experiments of electrospinning medical dressings at this stage, and prospects for the research of optimized electrospinning dressings for bionic skin are put forward.

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备注/Memo

备注/Memo:
收稿日期:2021-05-08;改回日期:2022-02-24。
基金项目:陕西省重点研发计划一般项目(2022NY-042)
通讯作者:杨冬(1979-),女,博士,副教授,硕士生导师,主要研究方向为生物及化学传感、纳米生物检测。E-mail:yangdong@sust.edu.cn;薛朝华(1974-),男,博士,教授,博士生导师,主要研究方向为功能超疏水材料的设计和制备以及复合功能涂层。E-mail:xuechaohua@126.com.
更新日期/Last Update: 2022-08-19