[1]高志亮,南蓓蓓,白阳,等.基于环糊精的高交联密度pH响应性水凝胶的制备与性能研究[J].高分子通报,2022,(10):74-86.[doi:10.14028/j.cnki.1003-3726.2022.10.009]
 GAO Zhi-liang,NAN Bei-bei,BAI Yang,et al.The Preparation and Application of pH-Responsive β-Cyclodextrin-based Hydrogel with High Cross-linked Density[J].POLYMER BULLETIN,2022,(10):74-86.[doi:10.14028/j.cnki.1003-3726.2022.10.009]
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基于环糊精的高交联密度pH响应性水凝胶的制备与性能研究()
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《高分子通报》[ISSN:1003-3726/CN:11-2051/O6]

卷:
期数:
2022年10期
页码:
74-86
栏目:
出版日期:
2022-10-20

文章信息/Info

Title:
The Preparation and Application of pH-Responsive β-Cyclodextrin-based Hydrogel with High Cross-linked Density
作者:
高志亮1 南蓓蓓1 白阳2 乔红军1
1. 陕西延长石油(集团)有限责任公司研究院, 西安 710065;
2. 陕西科技大学化学与化工学院, 西安 710021
Author(s):
GAO Zhi-liang1 NAN Bei-bei1 BAI Yang2 QIAO Hong-jun1
1. Research Institute of Shaanxi Yanchang Petroleum(group)Co., Ltd, Xi’an 710065, China;
2. College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China
关键词:
动态化学键β-环糊精席夫碱反应自愈合
Keywords:
Dynamic chemical bondβ-cyclodextrinSchiff base reactionSelf-healing property
DOI:
10.14028/j.cnki.1003-3726.2022.10.009
文献标志码:
A
摘要:
本文选用β-环糊精和聚乙二醇两种生物相容性材料,通过向体系中引入动态化学键,快速构筑了具有自愈合性能的pH响应性水凝胶。首先,通过对β-环糊精6位羟基的全碘代、全叠氮以及全胺化反应,合成了6-位全胺基取代环糊精(β-CD-(NH2)7);接下来通过聚乙二醇(2K)和对羧基苯甲醛的酯化反应合成苯甲醛基封端的聚乙二醇(PEG-FA)。通过傅里叶变换红外光谱仪(FT-IR)、核磁共振氢谱(1H-NMR)、核磁共振碳谱(13C-NMR)、基质辅助激光解吸电离飞行时间质谱(Maldi-TOF-MS)对产物进行结构表征,结果与预期相符。其次,通过6-位全取代胺化环糊精(β-CD-(NH2)7)和苯甲醛基封端聚乙二醇(PEG-2FA)的席夫碱反应制备了基于可逆动态化学键的pH响应性水凝胶,并对水凝胶的最低凝胶浓度,溶胶凝胶转变、自愈合性能以及体外药物释放性能、体外细胞毒性进行研究。所构筑的水凝胶通过感应pH变化,可实现可逆化学键的断裂和重组,在溶胶与凝胶之间建立动态平衡关系,从而完成水凝胶的生成-破损-愈合过程;体外药物释放性能实验发现pH的刺激可加速水凝胶的药物释放行为;基础细胞实验表明,水凝胶的细胞毒性较低,在癌症治疗中具有潜在的应用价值。
Abstract:
In this paper, the pH-responsive hydrogels with self-healing properties were rapidly constructed by introducing dynamic chemical acylhydrazone bonds. Firstly, the cross-linkage(β-CD-(NH2)7) with certain seven reactional points were synthesized by the reaction of iodine, azide and amination of whole 6-OH of β-cyclodextrin. Then, benzaldehyde-terminated polyethylene glycol(PEG-FA) was synthesized by esterification of polyethylene glycol and p-carboxybenzaldehyde. Fourier transform infrared spectroscopy(FT-IR), 1H-NMR, 13C-NMR and matrix-assisted laser desorption ionization time-of-flight mass spectrometry(Maldi-TOF-MS) were used to characterize the products. Secondly, the pH response hydrogels based on reversible dynamic chemical bond were prepared by schiff base reaction of β-CD-(NH2)7 and PEG-FA. The lowest gel concentration, sol-gel transition and self-healing ability of the hydrogel were also studied. Through the response of external pH, the reversible chemical bonds can be broken and recombined, and the dynamic equilibrium relationship between reactants and generators can be established to complete the hydrogel formation-breakage-healing process. Basic cell experiments can also prove the potential application of the synthesized hydrogel.

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备注/Memo

备注/Memo:
收稿日期:2021-10-19;改回日期:2022-2-11。
基金项目:国家自然科学基金(21801162)
作者简介:高志亮(1984-),男,硕士,高级工程师,研究方向为高分子材料合成与改性、油气田应用高分子材料研发
通讯作者:白阳(1988-),男,博士,副教授,研究方向为功能高分子材料合成和改性。E-mail:baiyang@sust.edu.cn.
更新日期/Last Update: 2022-09-20